Identification of gene clusters associated with fusaric acid, fusarin, and perithecial pigment production in Fusarium verticillioides
نویسندگان
چکیده
منابع مشابه
Transformation of Fusarium verticillioides with a polyketide gene cluster isolated from a fungal endophyte activates the biosynthesis of fusaric acid
A large number of bioactive natural products have been isolated from plant endophytic fungi. However, molecular mechanisms for the biosynthesis of these metabolites have lagged behind because genetic and biochemical studies are difficult to perform within many of the endophytes. In this work, we describe our attempt to express a putative mycoepoxydiene (MED) biosynthetic gene cluster in Fusariu...
متن کاملIdentification and regulation of fusA, the polyketide synthase gene responsible for fusarin production in Fusarium fujikuroi.
Fusarins are a class of mycotoxins of the polyketide family produced by different Fusarium species, including the gibberellin-producing fungus Fusarium fujikuroi. Based on sequence comparisons between polyketide synthase (PKS) enzymes for fusarin production in other Fusarium strains, we have identified the F. fujikuroi orthologue, called fusA. The participation of fusA in fusarin biosynthesis w...
متن کاملProduction of Fusaric Acid by Fusarium spp. in Pure Culture and in Solid Medium Co-Cultures.
The ability of fungi isolated from nails of patients suffering from onychomycosis to induce de novo production of bioactive compounds in co-culture was examined. Comparison between the metabolite profiles produced by Sarocladium strictum, by Fusarium oxysporum, and by these two species in co-culture revealed de novo induction of fusaric acid based on HRMS. Structure confirmation of this toxin, ...
متن کاملGenotyping of Fusarium verticillioides strains producing fumonisin B1 in feed associated with animal health problems
Fusarium verticillioides (F. verticillioides) is not only a primary pathogen of maize, but also can causedisease in other crops such as sorghum. Pathogenicity is related to mycotoxin production such as fumonisin.In the present study, 24 isolates of F. verticillioides, which were previously identified by phenotype basedmethods, were re-identified using restriction fragment length polymorphism (R...
متن کاملLae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides.
The filamentous fungus Fusarium verticillioides can cause disease of maize and is capable of producing fumonisins, a family of toxic secondary metabolites linked to esophageal cancer and neural tube defects in humans and lung edema in swine and leukoencephalomalacia in equines. The expression of fumonisin biosynthetic genes is influenced by broad-domain transcription factors (global regulators)...
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ژورنال
عنوان ژورنال: Fungal Genetics and Biology
سال: 2012
ISSN: 1087-1845
DOI: 10.1016/j.fgb.2012.05.010