Identifying Candidate Oocyte Reprogramming Factors Using Cross-Species Global Transcriptional Analysis
نویسندگان
چکیده
منابع مشابه
Metagene projection for cross-platform, cross-species characterization of global transcriptional states.
The high dimensionality of global transcription profiles, the expression level of 20,000 genes in a much small number of samples, presents challenges that affect the sensitivity and general applicability of analysis results. In principle, it would be better to describe the data in terms of a small number of metagenes, positive linear combinations of genes, which could reduce noise while still c...
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a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...
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ژورنال
عنوان ژورنال: Cellular Reprogramming
سال: 2013
ISSN: 2152-4971,2152-4998
DOI: 10.1089/cell.2012.0060