IFT88 controls NuMA enrichment at k-fibers minus-ends to facilitate their re-anchoring into mitotic spindles
نویسندگان
چکیده
منابع مشابه
NuMA recruits dynein activity to microtubule minus-ends at mitosis
To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into poles. How dynein becomes enriched at minus-ends is not known. Here, we use quantitative imaging and laser ablation to show that NuMA targets ...
متن کاملThe spindle plays both ends
In order to correctly segregate during mitosis, sister chromatids must attach their kinetochores to stable microtubule (MT) bundles, known as K-fibers, that are connected to opposite spindle poles. In 1986, Marc Kirschner and Tim Mitchison proposed a “search and capture” model in which dynamic MTs emanating from the centrosomes would be selectively stabilized if their plus ends happened to cont...
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During cell division, the mitotic spindle assembles itself from its constituent parts. Spindle microtubule minus ends are focused into two poles, and these poles dictate where duplicated chromatids are transported at anaphase. Forces that focus microtubules into poles are crucial to spindle organization and function. Cytoplasmic dynein, a minus end–directed microtubule motor, clusters parallel ...
متن کاملThe minus k-domination numbers in graphs
For any integer , a minus k-dominating function is afunction f : V (G) {-1,0, 1} satisfying w) for every vertex v, where N(v) ={u V(G) | uv E(G)} and N[v] =N(v)cup {v}. The minimum of the values of v), taken over all minusk-dominating functions f, is called the minus k-dominationnumber and is denoted by $gamma_k^-(G)$ . In this paper, we introduce the study of minu...
متن کاملThe nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron.
Neurons are terminally post-mitotic cells that utilize their microtubule arrays for the growth and maintenance of axons and dendrites rather than for the formation of mitotic spindles. Recent studies from our laboratory suggest that the mechanisms that organize the axonal and dendritic microtubule arrays may be variations on the same mechanisms that organize the mitotic spindle in dividing cell...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-46605-x