Image-derived input function in PET brain studies
نویسندگان
چکیده
منابع مشابه
Image derived input function applied in CBF Studies with [15O]water PET in an integrated MR-PET
Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany To quantify CBF studies using [O]water PET an input function must be provided, e.g. by means of arterial blood sampling. An image derived input function (IDIF) gained from the dynamic PET images may be a non-invasive alternative. The time-activity curve (TAC) of the blood can be obtained from a volume of interest ...
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UNLABELLED Measurement of arterial input function is a restrictive aspect for quantitative (18)F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS In the present study, we took advantage of the high spatial resolution of a recent dedicated small-animal scanner to extract the input function from the (18)F-FDG PET ima...
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UNLABELLED Kinetic modeling of PET data derived from mouse models remains hampered by the technical inaccessibility of an accurate input function (IF). In this work, we tested the feasibility of IF measurement with an arteriovenous shunt and a coincidence counter in mice and compared the method with an image-derived IF (IDIF) obtained by ensemble-learning independent component analysis of the h...
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BACKGROUND Obtaining the arterial input function (AIF) from image data in dynamic positron emission tomography (PET) examinations is a non-invasive alternative to arterial blood sampling. In simultaneous PET/magnetic resonance imaging (PET/MRI), high-resolution MRI angiographies can be used to define major arteries for correction of partial-volume effects (PVE) and point spread function (PSF) r...
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Dynamic FDG-PET imaging was used to study inflammation in lungs of mice following administration of a virulent strain of Klebsiella (K.) pneumoniae. Net whole-lung FDG influx constant (K(i)) was determined in a compartment model using an image-derived blood input function. Methods. K. pneumoniae (~3 x 10(5) CFU) was intratracheally administered to six mice with 6 other mice serving as controls....
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ژورنال
عنوان ژورنال: Nuclear Medicine Communications
سال: 2012
ISSN: 0143-3636
DOI: 10.1097/mnm.0b013e328356185c