Immune Complex Formation after Xenotransplantation

Xenotransplantation: immune barriers beyond hyperacute rejection

1. The use of organs from animal donors (xenotransplantation) is a potential solution to the chronic shortage of allogeneic organs and currently the pig is thought to be the most suitable donor for man. However, porcine organs are rejected rapidly by a vascular process called hyperacute rejection which has so far prevented clinical xenotransplantation. Although it is likely that this barrier wi...

Immune complex formation in IgA nephropathy:

Immune Responses Following Mouse Peripheral Nerve Xenotransplantation in Rats

Xenotransplantation offers a potentially unlimited source for tissues and organs for transplantation, but the strong xenoimmune responses pose a major obstacle to its application in the clinic. In this study, we investigate the rejection of mouse peripheral nerve xenografts in rats. Severe intragraft mononuclear cell infiltration, graft distension, and necrosis were detected in the recipients a...

Modulation of the Immune Response in Concordant Xenotransplantation

Bersztel, A. 2003. Modulation of the Immune Response in Concordant Xenotransplantation. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1258. 57 pp. Uppsala. ISBN 91554-5622-7 Xenotransplantation, i.e. transplantation between different species, could be a possible solution to the present shortage of organ donors. The immunological re...

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immune effector cells, triggering a coordinated anti-cancer immune response. Herein, using whole blood...