Immune infiltrating cells in cholangiocarcinoma may become clinical diagnostic markers: based on bioinformatics analysis

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor originating from the secondary bile duct and its branch epithelium. Among primary liver tumors, incidence of ICC second only to hepatocellular carcinoma. Tumor microenvironment can regulate occurrence development tumors. This study dedicated finding more markers that diagnose by differential cells between normal tissues. Methods We wanted infiltration immune same patient paired non-tumor tissues, explore difference in adjacent tissues organism. So, we searched relevant data patients with GEO database found GSE45001 set meets our research needs. CIBERSORT used calculate cell composition. Finally, perform visual analysis statistics find out differentially expressed cells. Results expression levels dendritic activated, macrophages M2, T regulatory (Tregs) were higher than M1, monocytes, follicular helper lower Conclusion These 6 types are expected become molecular for clinical diagnosis ICC.