Impaired Dendritic Cell Migration and T cell Stimulation in Aging Lead to Defective Dendritic Cell‐Mediated Antitumor Immunity
نویسندگان
چکیده
منابع مشابه
Impaired dendritic cell function in aging leads to defective antitumor immunity.
We recently reported that bone marrow-derived dendritic cells (DC) from aged miced are less effective than their young counterparts in inducing the regression of B16-ovalbumin (OVA) melanomas. To examine the underlying mechanisms, we investigated the effect of aging on DC tumor antigen presentation and migration. Although aging does not affect the ability of DCs to present OVA peptide((257-264)...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1076.2