Implications of Clinical Trial Design on Sample Size Requirements
نویسندگان
چکیده
منابع مشابه
Implications of clinical trial design on sample size requirements.
The primary goal in designing a randomized controlled clinical trial (RCT) is to minimize bias in the estimate of treatment effect. Randomized group assignment, double-blinded assessments, and control or comparison groups reduce the risk of bias. The design must also provide sufficient statistical power to detect a clinically meaningful treatment effect and maintain a nominal level of type I er...
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SAMPLE SIZE MUST BE PLANNED carefully to ensure that the research time, patient effort and support costs invested in any clinical trial are not wasted. Item 7 of the CONSORT statement relates to the sample size and stopping rules of studies (see Box 1); it states that the choice of sample size needs to be justified. 1 Ideally, clinical trials should be large enough to detect reliably the smalle...
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Background and Purpose: The purpose of this study was to analyze recovery of motor function in a cohort of patients presenting with an acute occlusion in the carotid distribution. Analysis of recovery patterns is important for estimating patient care needs, establishing therapeutic plans, and estimating sample sizes for clinical intervention trials. Methods: We prospectively measured the motor ...
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We estimate the number of training samples required to ensure that the performance of a neural network on its training data matches that obtained when fresh data is applied to the network. Existing estimates are higher by orders of magnitude than practice indicates. This work seeks to narrow the gap between theory and practice by transforming the problem into determining the distribution of the...
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The problem of choosing a sample size for a clinical trial is a very common one. In some settings, such as rare diseases or other small populations, the large sample sizes usually associated with the standard frequentist approach may be infeasible, suggesting that the sample size chosen should reflect the size of the population under consideration. Incorporation of the population size is possib...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2007
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbn035