Importin-β: Structural and Dynamic Determinants of a Molecular Spring
نویسندگان
چکیده
منابع مشابه
Importin-beta: structural and dynamic determinants of a molecular spring.
The beta-karyopherin/RanGTP system constitutes the largest known family of cellular cargo transporters. The flexibility of the karyopherin transport receptors is the key to their versatility in binding cargoes of different shape and size. Despite strong binding of the Ran complex, the comparably low energy associated with GTP hydrolysis suffices to drive dissociation and fuel the transport cycl...
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Chiral β-amino acids occur as constituents of various natural and synthetic compounds with potentially useful bioactivities. The pyridoxal 5'-phosphate (PLP)-dependent S-selective transaminase from Mesorhizobium sp. strain LUK (MesAT) is a fold type I aminotransferase that can be used for the preparation of enantiopure β-Phe and derivatives thereof. Using x-ray crystallography, we solved struct...
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ژورنال
عنوان ژورنال: Structure
سال: 2008
ISSN: 0969-2126
DOI: 10.1016/j.str.2008.03.007