Improved statistical tests for differential gene expression by shrinking variance components estimates
نویسندگان
چکیده
منابع مشابه
Improved statistical tests for differential gene expression by shrinking variance components estimates.
Combining information across genes in the statistical analysis of microarray data is desirable because of the relatively small number of data points obtained for each individual gene. Here we develop an estimator of the error variance that can borrow information across genes using the James-Stein shrinkage concept. A new test statistic (FS) is constructed using this estimator. The new statistic...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2004
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxh018