Improvement in Intestinal-Failure-Associated Liver Disease by Using Parenteral Fish Oil as Monotherapy: Case-Based Review of the Literature
نویسندگان
چکیده
Intestinal-failure-associated liver disease (IFALD) is a common complication of prolonged parenteral nutrition (PN). Risk factors for IFALD include clinical features, as well medical interventions, and its management was initially based on the decrease or interruption while increasing enteral nutrition. However, tolerance full in children with intestinal failure may require rehabilitation over period years. As consequence, infants unable to wean from PN are prone develop end-stage disease. We describe case an infant receiving long-term who diagnosed wherein we were able reverse by switching lipid emulsions fish oil monotherapy. A systemic review reports series reversing using emulsion follows description.
منابع مشابه
[Exclusively based parenteral fish-oil emulsion (Omegaven®) in the treatment of parenteral nutrition associated liver disease: Report of a case].
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The use of fish oil-based lipid emulsions (FOLE) in the treatment of intestinal failure-associated liver disease (IFALD) remains investigational. Additional evidence for safety and efficacy, particularly in the neonatal and pediatric populations, is needed. Retrospective chart review was conducted on 10 infants with short bowel syndrome who received FOLE for IFALD. Direct bilirubin concentratio...
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Since 2004, fish oil based lipid emulsions have been used in the treatment of intestinal failure associated liver disease, with a noticeable impact on decreasing the incidence of morbidity and mortality of this often fatal condition. With this new therapy, however, different approaches have emerged as well as concerns about potential risks with using fish oil as a monotherapy. This review will ...
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BACKGROUND Parenteral nutrition-associated liver disease can be a progressive and fatal entity in children with short-bowel syndrome. Soybean-fat emulsions provided as part of standard parenteral nutrition may contribute to its pathophysiology. METHODS We compared safety and efficacy outcomes of a fish-oil-based fat emulsion in 18 infants with short-bowel syndrome who developed cholestasis (s...
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Published data assessing the efficacy and toxicity of omega-3 fatty acid emulsion in children are limited. Until recently, children requiring long-term parenteral nutrition who experienced parenteral nutrition–associated liver disease (PNALD) were likely to die from infection or liver disease before receiving a small bowel and/or liver transplant. With the introduction of parenteral fish oil (1...
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ژورنال
عنوان ژورنال: Reports
سال: 2023
ISSN: ['2571-841X']
DOI: https://doi.org/10.3390/reports6020028