Improvement of PHBV Scaffolds with Bioglass for Cartilage Tissue Engineering

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Improvement of PHBV Scaffolds with Bioglass for Cartilage Tissue Engineering

Polymer scaffold systems consisting of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) have proven to be possible matrices for the three-dimensional growth of chondrocyte cultures. However, the engineered cartilage grown on these PHBV scaffolds is currently unsatisfactory for clinical applications due to PHBV's poor hydrophilicity, resulting in inadequate thickness and poor biomechanical proper...

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Scaffolds have an important role in cartilage tissue engineering. Poly(hydroxybutyrate‑co‑hydroxyvalerate) (PHBV) has been demonstrated to have potential as a scaffold for the three dimensional construction of engineered cartilage tissue. However, the poor hydrophilicity and mechanical strength associated with PHBV affects its clinical applications as a scaffold in cartilage tissue engineering....

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Polyhydroxybutyrate–polyhydroxyvalerate (PHBV) and bioglass (BG) have been widely reported to be suitable for bone tissue engineering. However, composite scaffolds with polymers and bioceramics have shown advantages over pure polymer and bioceramic scaffolds for bone tissue engineering. In addition, recent studies have shown that cross-talk between endothelial cells and osteoblastic cells can s...

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her willingness to meet with me and for her expert feedback. Jeannette Yen have also been very insightful and provided me with invaluable direction during the proposal of my work. I would also like to thank my fellow past and present lab members: Dr. Lastly, I would like to thank my dear fiancée Deena for her love and support during the last part of my PhD. It was her love and kindness that kep...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2013

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0071563