Inactivation of Cephalothin and Cephaloridine by Staphylococcus aureus

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Inactivation of cephalothin and cephaloridine by Staphylococcus aureus.

Benner, Ernest J. (University of Washington School of Medicine, Seattle), John V. Bennett, Jean L. Brodie, and William M. M. Kirby. Inactivation of cephalothin and cephaloridine by Staphylococcus aureus. J. Bacteriol. 90:1599-1604. 1965.-Marked differences were observed in the susceptibility of penicillinase-producing staphylococci to cephalothin and cephaloridine. All of 100 strains of penicil...

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Sensitivity of penicillinase-forming strains of Staphylococcus aureus and of their penicillinase-negative variants to cephaloridine, cephalothin, methicillin, and benzylpenicillin.

Twenty-eight penicillinase-forming cultures of Staphylococcus aureus and their penicillinase-negative variants were examined for resistance to benzylpenicillin, methicillin, cephalothin, and cephaloridine. The results supported the view that cephaloridine was more easily destroyed by staphylococcal penicillinase than was cephalothin. In our tube-dilution tests, the minimum inhibitory concentrat...

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Inactivation of vancomycin-induced unstable L-forms of Staphylococcus aureus by horse serum

Substitution at codon Ser315 of katG gene, a reliable marker for isoniazid (INH) resistance and proliferate in spite of the loss of cell wall is called an L- form. Unstable L- forms  can convert to normal cells but stble L-forms can not.cell wall - deffective state may be induced spontaneously or through the action of an appropriate agent such as antibiotic interfering with the synthesis of cel...

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Inactivation of dihydrostreptomycin and spectinomycin by Staphylococcus aureus.

Three types of Staphylococcus aureus strains were isolated with respect to streptomycin (SM) and spectinomycin (SPC) resistance, namely, SM(r)SPC(r), SM(r)SPC(s), and SM(s)SPC(r) (r, resistant; s, sensitive). Curing experiments and transduction analysis of strain MS7990 (SM(r).SPC(r).EM(r)) (EM, erythromycin) disclosed that the loci governing SM and SPC resistance are different and exist on dif...

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Double-blind comparison of cephacetrile with cephalothin-cephaloridine.

Under double-blind protocol, a controlled comparison was made between a new cephalosporin, cephacetrile, and cephalothin or cephaloridine. The patient's primary physician determined the indications for treatment, and the dosage was uniform for each route of administration. Infecting strains of staphylococci and Proteus mirabilis had a lower median inhibitory concentration for cephalothin than c...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1965

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.90.6.1599-1604.1965