Increased Ribavirin Bioavailability Associated With Telaprevir Use in Hepatitis C Patients Treated With PEGylated -Interferon/Ribavirin/Telaprevir Triple Therapy
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چکیده
منابع مشابه
increased ribavirin bioavailability associated with telaprevir use in hepatitis c patients treated with pegylated -interferon/ribavirin/telaprevir triple therapy
conclusions our results indicated a reversible increase in rbv bioavailability after telaprevir exposure, which might be linked to the impairment of the gfr. this also suggests a rbv-telaprevir pharmacological interaction, a possible source of severe anemia observed under triple therapy. these results suggest that rbv pharmacological monitoring may be clinically relevant, especially in the cont...
متن کاملIncreased Ribavirin Bioavailability Associated With Telaprevir Use in Hepatitis C Patients Treated With PEGylated -Interferon/Ribavirin/Telaprevir Triple Therapy
BACKGROUND Anemia is more frequent in patients receiving telaprevir with PEGylated interferon/ribavirin (PEG-IFN/RBV) than in those receiving PEG-IFN/RBV alone. OBJECTIVES The objective was to measure the impact of telaprevir on RBV bioavailability and to assess the concomitant renal function. MATERIALS AND METHODS Thirty-seven hepatitis C virus (HCV) patients non-responders to a previous c...
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Telaprevir combination with pegylated-interferon (Peg-IFN) +ribavirin significantly improves response rates in HCV infection.1-3 However this triple regimen is particularly associated with increased rates of side effects.4 HCV infection in patients undergoing hematopoietic stem cell transplantation (HSCT) increases the risks of liver-related complications and veno-occlusive disorder.5,6 Cure of...
متن کاملTelaprevir impairs renal function and increases blood ribavirin concentration during telaprevir/pegylated interferon/ribavirin therapy for chronic hepatitis C
We aimed to examine the relationship between renal dysfunction and anaemia that may develop during combination therapy involving pegylated interferon, ribavirin and telaprevir (PEG-IFN/RBV/TVR) for the treatment of chronic hepatitis C. Sixty-eight patients with genotype 1b high viral loads were treated with PEG-IFN/RBV/TVR. Peg-IFN and RBV doses were administered according to body weight. TVR w...
متن کاملDepressive Episode Incidence in Patients with Chronic Hepatitis C Treated with Pegylated Interferon and Ribavirin.
BACKGROUND The effectiveness of antiviral therapy with pegylated interferon and ribavirin for chronic hepatitis C is far from ideal and presents several adverse events. Among such events, there is the depressive episode that can even lead to treatment discontinuity. OBJECTIVE Analyze the incidence of depressive episodes in patients with chronic hepatitis C treated with pegylated interferon (I...
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ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2015
ISSN: 1735-143X,1735-3408
DOI: 10.5812/hepatmon.28879