Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.

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Induction of suppressor activity in the autologous mixed lymphocyte reaction and in cultures with concanavalin A.

T lymphocytes that are activated in the autologous mixed lymphocyte reaction (MLR) have suppressor activity. Concanavalin A (Con A) augments the suppressor activity generated in cultures containing both T and non-T lymphocytes and can induce suppressor activity in T-lymphocyte preparations that contain too few (10%) non-T cells to generate a significant autologous MLR. However, when such T-lymp...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1979

ISSN: 0021-9738

DOI: 10.1172/jci109622