Infections, Immunity, and Atherosclerosis


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Immunity and Atherosclerosis

Atherosclerotic plaque formation is strongly influenced by different arms of the immune system, including B lymphocytes. B cells are divided into 2 main families: the B1 and the B2 cells. B1 cells are atheroprotective mainly via the production of natural IgM antibodies that bind oxidized low-density lipoprotein and apoptotic cells. B2 cells, which include follicular and marginal zone B cells, a...

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Host genetic factors play a central role in determining the clinical phenotype of human diseases. Association between two polymorphic loci in human genome, human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIRs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. Hence, defining the influence of genetic di...

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Immunity, atherosclerosis and cardiovascular disease

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عنوان ژورنال: Circulation

سال: 2000

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.102.8.833