Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements
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چکیده
منابع مشابه
Supralinear Ca2+ Signaling by Cooperative and Mobile Ca2+ Buffering in Purkinje Neurons
Endogenous high-affinity Ca2+ buffering and its roles were investigated in mouse cerebellar Purkinje cells with the use of a low-affinity Ca2+ indicator and a high-affinity caged Ca2+ compound. Increases in the cytosolic Ca2+ concentration ([Ca2+]i) were markedly facilitated during repetitive depolarization, resulting in the generation of steep micromolar Ca2+ gradients along dendrites. Such su...
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Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber axons of granule cells that contact vertic...
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that mice deficient in calbindin-D 28K exhibit cerebellar ataxia (Airaksinen et al., 1997a) and impaired spatial Hongo, Bunkyo-ku Tokyo 113 learning (Molinari et al., 1996). However, the properties of high-affinity Ca 2ϩ buffering in vivo and its specific Japan † Department of Pharmacology and Physiology consequences for neuronal Ca 2ϩ signaling have not been elucidated. We have therefore now i...
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We combined local photolysis of caged compounds with fluorescence imaging to visualize molecular diffusion within dendrites of cerebellar Purkinje cells. Diffusion of a volume marker, fluorescein dextran, within spiny dendrites was remarkably slow in comparison to its diffusion in smooth dendrites. Computer simulations indicate that this retardation is due to a transient trapping of molecules w...
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Climbing fiber discharges within the rat cerebellar cortex have been shown to display synchrony, especially for climbing fibers terminating in the same parasagittal bands. In addition, Purkinje cells which have the smallest rostrocaudal separation also seem to have the highest degree of synchrony. But this has so far only been investigated for distances down to 250 mum. In the present study, we...
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ژورنال
عنوان ژورنال: eLife
سال: 2018
ISSN: 2050-084X
DOI: 10.7554/elife.36246