Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis
نویسندگان
چکیده
منابع مشابه
Subchondral Bone in Osteoarthritis
Osteoarthritis (OA) is characterised by progressive degenerative damage to articular cartilage, but ultimately the disease affects the whole joint, with important implications for the affected limb and the entire body (Martel-Pelletier and Pelletier, 2010; Edmonds, 2009). There has been an ongoing debate regarding the origins of OA, and specifically whether it initiates in the bone or the carti...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولTargeting subchondral bone in osteoporotic osteoarthritis
The identification of well-defined phenotypes along the course of the disease may open new avenues for personalized management in osteoarthritis (OA). In vivo research carried out in various animal models as well as epidemiological and clinical data support the existence of a particular phenotype - osteoporotic OA. In fact, subchondral bone has become a potential therapeutic target in OA. Depen...
متن کاملSubchondral Bone and Its Role in Osteoarthritis
Osteoarthritis (OA) is the most prevalent form of arthritis and one of the leading causes of chronic disability which is becoming more pronounced as the population ages. Various genetic, biologic and mechanical factors contribute to disease process in OA. A large cascade of events leads to breakdown and degeneration of cartilage in a progressive manner ultimately resulting in the damage of the ...
متن کاملSubchondral bone histology and grading in osteoarthritis
OBJECTIVE Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously. However, the histological features of subchondral bone are only poorly characterized in current histological grading scales of OA. The aim of this study i...
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ژورنال
عنوان ژورنال: Bone Research
سال: 2019
ISSN: 2095-6231
DOI: 10.1038/s41413-019-0071-x