Inhibition of Telomerase Activity Enhances Hyperthermia-Mediated Radiosensitization
نویسندگان
چکیده
منابع مشابه
Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization.
Hyperthermia is a potent sensitizer of cell killing by ionizing radiation (IR); however, hyperthermia also induces heat shock protein 70 (HSP70) synthesis and HSP70 expression is associated with radioresistance. Because HSP70 interacts with the telomerase complex and expression of the telomerase catalytic unit (hTERT) extends the life span of the human cells, we determined if heat shock influen...
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Objective: To investigate the effects of AZT-mediated inhibition of telomerase activity on the proliferation, apoptosis and radiosensitivity of panc1 cells, and the growth of pancreatic tumor in vivo. Methods: panc1 cells were divided into four groups: A, control group; B, 0.4 mmol/L AZT; C, 0.6 mmol/L AZT; and D, 0.8 mmol/L AZT group. Cell proliferation was assessed by MTT assay. Cell apoptosi...
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The terminal regions of human chromosomes, the telomeres, shorten with each cell division in most normal somatic cells. Telomerase, a ribonucleoprotein that synthesizes telomeric DNA onto chromosomal ends, is activated in germline cells and almost all tumor cells. Telomerase activity maintains the stability of telomere length, resulting in indefinite cellular proliferation (immortality). In the...
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A complex of Co(III) with a nitro group and a bis(2-chloroethyl)amine moiety was prepared in an effort to develop a new anticancer agent with radiosensitizing capabilities, direct antitumor activity, and the ability to interact positively with clinically relevant hyperthermia temperatures. The activity of this drug was compared to a similar Co(III) complex, nitro-bis(2,4-pentanedionato)(pyridin...
متن کاملCytotoxicity, radiosensitization, antitumor activity, and interaction with hyperthermia of a Co(III) mustard complex.
A complex of Co(III) with a nitro group and a bis(2-chloroethyl)amine moiety was prepared in an effort to develop a new anticancer agent with radiosensitizing capabilities, direct antitumor activity, and the ability to interact positively with clinically relevant hyperthermia temperatures. The activity of this drug was compared to a similar Co(III) complex, nitro-bis(2,4-pentanedionato)(pyridin...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2008
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-07-5831