Inhibition of Tissue Factor Pathway During Intermittent Pneumatic Compression

Inhibition of tissue factor pathway during intermittent pneumatic compression: A possible mechanism for antithrombotic effect.

Intermittent pneumatic compression (IPC) devices are an effective prophylaxis against lower extremity deep vein thrombosis. Their antithrombotic effect has been attributed to a reduction in venous stasis and enhanced fibrinolysis. The initiating mechanism for blood coagulation is the tissue factor (TF) dependent pathway, which is inhibited by tissue factor pathway inhibitor (TFPI). We have inve...

StarSystem Intermittent Pneumatic Compression

Intermittent pneumatic compression in fracture and soft-tissue injuries healing.

INTRODUCTION Current methods of fracture care use various adjuncts to try and decrease time to fracture union, improve fracture union rates and enhance functional recovery. Intermittent pneumatic compression (IPC), one such modality, is used in the management of both fractures and soft-tissue injuries. METHODS AND RESULTS A search of PubMed, Medline, CINAHL, DH data and Embase databases was p...

Intermittent pneumatic compression after stroke

www.thelancet.com/neurology Vol 13 December 2014 1163 Acute stroke often causes immobility, which predisposes to deep vein thrombosis and pulmonary embolism and these can be fatal or disabling. Low-dose subcutaneous anticoagulation with heparins and heparinoids reduces the risk of venous thromboembolism, but the benefi t is off set by haemorrhagic complications. Even targeting anticoagulation t...

Usefulness of intermittent pneumatic compression in medicine

Exist many studies documenting the use of intermittent pneumatic compression in lymphedema, venous ulcers, prophylaxis in deep vein thrombosis and limb ischaemia. This article discusses the basics and usefulness of this therapy based on available studies and recommendations. Because of lack serious side effects, good patient compliance and effectiveness intermittent pneumatic compression should...