Inhibitory Effects of Citrates in the Determination of Trace Amounts of Penicillin

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Inhibitory effects of citrates in the determination of trace amounts of penicillin.

In the microbiological assay for the determination of trace amounts of penicillin, it has been shown that sodium citrate and penicillin act synergistically against Sarcina lutea. The inhibitory action of citrate appears to involve a sequestering of divalent cations essential to the growth of the organism as shown by minimal inhibitory concentration and agar diffusion studies. The addition of ca...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1975

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.8.1.30