Instrumental variable meta-analysis Comment on: Adjustment for compliance behavior in trials of epidural analgesia in labor using instrumental variable meta-analysis
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چکیده
منابع مشابه
Instrumental variable meta-analysis of individual patient data: application to adjust for treatment non-compliance
BACKGROUND Intention-to-treat (ITT) is the standard data analysis method which includes all patients regardless of receiving treatment. Although the aim of ITT analysis is to prevent bias due to prognostic dissimilarity, it is also a counter-intuitive type of analysis as it counts patients who did not receive treatment, and may lead to "bias toward the null." As treated (AT) method analyzes pat...
متن کاملInstrumental variable analysis.
The main advantage of the randomized controlled trial (RCT) is the random assignment of treatment that prevents selection by prognosis. Nevertheless, only few RCTs can be performed given their high cost and the difficulties in conducting such studies. Therefore, several analytical methods for removing the effects of selection bias in observational studies have been proposed. The first aim of th...
متن کاملInstrumental variable analysis in randomized trials with non- compliance and observational pharmacoepidemiologic studies
Introduction Instrumental variable (IV) analysis potentially accounts for unmeasured confounding in observational studies, but it can also control for noncompliance in randomized trials. IV analysis requires that the IV is related to treatment status, yet independent of confounders of the treatment-outcome relation. This implies that in pharmacoepidemiologic scenarios where IV analysis is neede...
متن کاملAnalysis of Additive Instrumental Variable Models
We apply Bayesian methods to a model involving a binary endogenous regressor and an instrumental variable in which the functional forms of some of the covariates in both the treatment assignment and outcome distributions are unknown. Continuous and binary response variables are considered. Under the assumption that the functional form is additive in the covariates, we develop efficient Markov c...
متن کاملComparison of variance estimators for meta-analysis of instrumental variable estimates
Background Mendelian randomization studies perform instrumental variable (IV) analysis using genetic IVs. Results of individual Mendelian randomization studies can be pooled through meta-analysis. We explored how different variance estimators influence the meta-analysed IV estimate. Methods Two versions of the delta method (IV before or after pooling), four bootstrap estimators, a jack-knife ...
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ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2017
ISSN: 0895-4356
DOI: 10.1016/j.jclinepi.2017.07.013