Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells.
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منابع مشابه
Optimization and Construction of Human Insulin-like Growth Factor 1 Gene related to human health
Background and aims: Laron syndrome is a disease that treated by Insulin-like Growth Factor 1 (IGF-1). This protein is a single chain and has three disulfide bonds. People with Laron syndrome have low rates of cancer and diabetes, although they appear to be at increased risk of casual death due to their stature. IGF-1 is synthesized by many tissues and is secreted from liver as an endocrine hor...
متن کاملProduction and functional characterization of human insulin-like growth factor 1
Insulin-like growth factor 1 (IGF-1) is a polypeptide hormone produced mainly by the liver in response to the endocrine growth hormone (GH) stimulus. This protein is involved in a wide range of cellular functions, including cellular differentiation, transformation, apoptosis suppression, migration and cell-cycle progression and other metabolic processes. In the current study, human heart cDNA w...
متن کاملInsulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Insulin and insulin-like growth factor I (IGF-I) initiate cellular functions by activating their homologous tyrosine kinase receptors. In most mammalian cell types, this results in rapid tyrosine phosphorylation of a high-molecular-weight substrate termed insulin receptor substrate 1 (IRS-1). Previous studies suggest that IRS-1 may act as a "docking" protein that noncovalently associates with c...
متن کاملInsulin-like growth factor I receptor activity in human medulloblastomas.
Medulloblastomas represent about 25% of all pediatric intracranial neoplasms. These highly malignant tumors arise from the cerebellum affecting mainly children between ages 5 and 15. Although the etiology of medulloblastomas has not yet been elucidated, several reports suggest that insulin-like growth factor I (IGF-I) may contribute to the development of these tumors. Results of this study show...
متن کاملInsulin-like growth factor-I receptor in human oral cancer.
The purpose of the study was to evaluate the expression of IGF-IR in primary tumours and lymph node metastases of oral cancers and the correlation between expression of IGF-IR and some clinicopathological features. Fifty-seven (57) oral cancers were examined by immunohistochemical studies, using the avidin-biotin-peroxidase method. Our study included only oral cancers, classified histopathologi...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1999
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1999_4189