Insulin Resistance Is Associated With Enhanced Brain Glucose Uptake During Euglycemic Hyperinsulinemia: A Large-Scale PET Cohort
نویسندگان
چکیده
OBJECTIVE Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between and brain metabolism remains controversial. Our aim was to examine association of (BGU) during a euglycemic hyperinsulinemic clamp large sample study participants across wide range age sensitivity. RESEARCH DESIGN AND METHODS [18F]-fluorodeoxyglucose positron emission tomography (PET) data from 194 scanned under conditions were compiled single-center cohort. BGU quantified by fractional rate. We examined age, sex, M value clamp, steady-state free fatty acid levels, C-reactive protein HbA1c, presence type 2 diabetes with using Bayesian hierarchical modeling. RESULTS Insulin sensitivity, indexed value, associated negatively all regions, confirming that insulin-resistant enhanced hyperinsulinemia. In addition, additional increase BGU. On contrary, related Steady-state HbA1c not CONCLUSIONS this cohort either sex sensitivity best predictor
منابع مشابه
Insulin resistance in euglycemic cirrhosis
BACKGROUND Insulin resistance (IR) is associated with hepatic fibrosis and cirrhosis, regardless of its etiology but the mechanism of hyperinsulinemia in cirrhosis is still unclear. The current study was designed to assess hyperinsulinemia and pancreatic β-cell function in euglycemic cirrhosis of varied etiology. METHODS A cross sectional case control study of 100 subjects. IR was assessed by...
متن کاملInsulin Resistance and Hyperinsulinemia
OBJECTIVE Recently, it has been suggested that insulin resistance and hyperinsulinemia can exist in isolation and have differential impacts on cardiovascular disease (CVD). To evaluate this suggestion, we assessed the degree of discordance between insulin sensitivity and insulin response in a healthy, nondiabetic population. RESEARCH DESIGN AND METHODS Insulin sensitivity was quantified by de...
متن کاملMicrovascular impairment is associated with insulin resistance in euglycemic mild hypertensives.
BACKGROUND Hypertension and diabetes are significantly associated with insulin resistance (IR), which could affect the vasodilatory capacity and microcirculation. The aim of the study was to verify whether IR is associated with a reduced microvascular blood flow in normoglycemic mild hypertensives. METHODS Eighty-four untreated grade-1 hypertensives were equally divided, according to the IR h...
متن کاملInsulin resistance and glucose transporter expression during the euglycemic hyperinsulinemic clamp in the lamb.
Three- to six-day-old lambs infused with 100 mU ⋅ kg-1 ⋅ min-1insulin required greater amounts of glucose to maintain euglycemia during a euglycemic hyperinsulinemic clamp compared with 31- to 35-day-old insulin-infused lambs (15.87 ± 3.47 vs. 4.30 ± 1.11 mg ⋅ kg-1 ⋅ min-1, P < 0.05, respectively). Endogenous glucose production persisted in both groups; however, the percent decrease compared wi...
متن کاملGlucose uptake during centrally induced stress is insulin independent and enhanced by adrenergic blockade.
Glucose utilization increases markedly in the normal dog during stress induced by the intracerebroventricular (ICV) injection of carbachol. To determine the extent to which insulin, glucagon, and selective (alpha/beta)-adrenergic activation mediate the increment in glucose metabolic clearance rate (MCR) and glucose production (R(a)), we used five groups of normal mongrel dogs: 1) pancreatic cla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes Care
سال: 2021
ISSN: ['1935-5548', '0149-5992']
DOI: https://doi.org/10.2337/dc20-1549