Insulin‑like growth factor 1/insulin‑like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells
نویسندگان
چکیده
منابع مشابه
Picropodophyllin inhibits the growth of Ewing's sarcoma cells through the insulin‑like growth factor‑1 receptor/Akt signaling pathway.
Ewing's sarcoma (ES) is the second most common type of pediatric bone tumor, and is associated with a poor prognosis. Picropodophyllin (PPP), a novel selective inhibitor of insulin‑like growth factor‑1 receptor (IGF‑1R), is able to strongly inhibit various types of cancers. However, the effect of IGF‑1R on ES remains unclear. Following treatment with various concentrations of PPP for various ti...
متن کاملTransforming growth factor- pathway activity in glioblastoma
Transforming growth factor (TGF)-� is a central molecule maintaining the malignant phenotype of glioblastoma. Anti-TGF-� strategies are currently being explored in early clinical trials. Yet, there is little contemporary data on the differential expression of TGF-� isoforms at the mRNA and protein level or TGF-�/Smad pathway activity in glioblastomas in vivo.Here we studied 64 newly diagnosed a...
متن کاملSecretion of insulinlike growth factor I and insulinlike growth factor-binding proteins by murine bone marrow stromal cells.
Insulin-like growth factor I (IGF-I) stimulates hematopoiesis. We examined whether bone marrow stromal cells synthesize IGF-I. Secretion of IGF-I immunoreactivity by cells from TC-1 murine bone marrow stromal cells was time-dependent and inhibited by cycloheximide. Gel filtration chromatography under denaturing conditions of TC-1 conditioned medium demonstrated two major peaks of apparent IGF-I...
متن کاملTumor necrosis factor-like weak inducer of apoptosis induces astrocyte proliferation through the activation of transforming-growth factor-α/epidermal growth factor receptor signaling pathway.
Reactive astrogliosis is beneficial in many aspects; however, it is also detrimental in some pathological states such as the development of lethal brain tumors. It is therefore crucial to understand the mechanisms regulating astrocyte proliferation. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor family, was shown to stimulate astrocyte prolif...
متن کاملEpidermal growth factor receptor in glioblastoma
Mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in glioblastoma. Enhanced activation of EGFR can occur through a variety of different mechanisms, both ligand-dependent and ligand-independent. Numerous evidence has suggested that EGFR is overexpressed in most of primary glioblastomas and some of the secondary glioblastomas and is characteristic of more aggressive ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2018
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2018.6336