Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
نویسندگان
چکیده
منابع مشابه
Extracellular Matrix (ECM)
18.1 Context of the ECM ...................................................... 461 18.1.1 ECM – What’s in a Name? ............................................. 462 18.1.2 Old and New ECMs ........................................................ 462 18.1.3 Biophysical Considerations ............................................. 462 18.1.4 Jelly Bombs ................................................
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Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton and transduce mechanical forces generated by the actin retrograde flow and myosin II t...
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متن کاملIntegrins and extracellular matrix in mechanotransduction.
Integrins bind extracellular matrix fibrils and associate with intracellular actin filaments through a variety of cytoskeletal linker proteins to mechanically connect intracellular and extracellular structures. Each component of the linkage from the cytoskeleton through the integrin-mediated adhesions to the extracellular matrix therefore transmits forces that may derive from both intracellular...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424
DOI: 10.1073/pnas.031562998