Inter-Grade and Inter-Batch Variability of Sodium Alginate Used in Alginate-Based Matrix Tablets
نویسندگان
چکیده
منابع مشابه
Evaluation of hydrophilic matrix tablets based on Carbopol(®) 971P and low-viscosity sodium alginate for pH-independent controlled drug release.
BACKGROUND The aim of this study was to evaluate matrix tablets containing different ratios of Carbopol(®) 971P (CP) to low-viscosity sodium alginate (SA) and assess their suitability for pH-independent controlled drug release. METHODS Two processing methods (physical mixing, PM and spray-drying, SD) were applied before compaction and the release from corresponding matrices was compared. The ...
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Sir, Sodium alginate consisting chiefly of the sodium salt o. alginic acio is widely used fOI its suspending, emulsifying, thickening and water binding properties (1,2.). Besides its utility at other places in pharmacological laboratories it is one of the popular emulsifiers, used to bring various substances into emulsion for experimental purposes. While conducting toxicity studies of some drug...
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Lamivudine, a BCS Class I synthetic nucleoside analogue, has a a short biological half-life of 5–7 and is mainly absorbed in the upper gastrointestinal tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as matrix formers a...
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Background: Although advantages of immobilization of cells through entrapment in calcium alginate gel beads have already been demonstrated, nevertheless, instability of the beads and the mass transfer limitations remain as the major challenges.Objective: The objective of the present study was to increase the stability, porosity (reduce mass transfer limit...
متن کاملDiffusion coefficients in viscous sodium alginate solutions
Department of Applied Physics, University of Fukui, Bunkyo 3-9-1, Fukui, 910-8507 Japan Abstract Sodium alginate solution, being viscous hydrocolloid, was examined voltammetrically in the context of viscous effects by use of a ferrocenyl compound as a redox probe. Voltammograms were almost independent of concentrations of sodium alginate even in a solid-like state. Diffusion coefficients of the...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2014
ISSN: 1530-9932
DOI: 10.1208/s12249-014-0154-3