Interaction of uromodulin and complement factor H enhances C3b inactivation
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چکیده
منابع مشابه
Interaction of uromodulin and complement factor H enhances C3b inactivation
Recent studies suggest that uromodulin plays an important role in chronic kidney diseases. It can interact with several complement components, various cytokines and immune system cells. Complement factor H (CFH), as a regulator of the complement alternative pathway, is also associated with various renal diseases. Thus, we have been suggested that uromodulin regulates complement activation by in...
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متن کاملAn investigation of the interaction between human complement factor H and C3b.
The complement system in human blood is a major effector system in humoraVinnate immunity (1). Factor H is a 155kD glycoprotein which is involved in the regulation of the complement alternative pathway (2). Factor H regulates C3 turnover by 2 activities: decay acceleration activity describes the ability of factor H to bind to C3b thus displacing Bb from the active C3bBb enzyme (C3 convertase) o...
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Various amounts of the activation fragment C3b of the complement (C) protein C3 were coupled to Sepharose 4B by catalysis with the C3 convertase of the alternative pathway of C. The binding of radioactively labelled C proteins B and H (= factor H) to the C3b-carrying particles was assayed. It was found that the relative binding of H, but not of B, fell rapidly with decreasing densities of solid...
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Nascent C3b can form ester bonds with various target molecules on the cell surface and in the fluid phase. Previously, we showed that C3b(2)--IgG complexes represent the major covalent product of C3 activation in serum [Lutz, Stammler, Jelezarova, Nater and Späth (1996) Blood 88, 184--193]. In the present report, binding of alternative pathway proteins to purified C3b(2)--IgG complexes was stud...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2016
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.12872