Interactions between the mannose receptor and thyroid autoantigens
نویسندگان
چکیده
منابع مشابه
Precipitation of the thyrotropin receptor and identification of thyroid autoantigens using Graves' disease immunoglobulins.
The thyrotropin (TSH) receptor is a putative target for autoantibodies in Graves' hyperthyroidism and therefore, should be capable of being identified, isolated, and structurally characterized by immunological means. To this end, four sera from patients with hyperthyroidism, three of which inhibited the binding of 125I-TSH to Triton-solubilized human thyroid membranes, were used to isolate TSH ...
متن کاملThyroxine-thyroid hormone receptor interactions.
Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs alpha and beta) that bind triiodothyronine (T(3), 3,5,3'-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T(4), 3,5,3',5'-tetraiodo-l-thyronine) with lower affinity. T(4) contains a bulky 5' iodine group absent from T(3). Because T(3) is buried in the core of the ligand binding domain (LBD), we have predict...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2005
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2004.02689.x