Interactions of nanoparticles with pulmonary structures and cellular responses
نویسندگان
چکیده
منابع مشابه
Interactions of nanoparticles with pulmonary structures and cellular responses.
Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers and clinicians for two main reasons. 1) Inhalation exposure to combustion-derived NSP was associated with increased pulmonary and cardiovascular morbidity and mortality as suggested by epidemiological studies. Experimental evidence has provided a mechanistic picture of the a...
متن کاملInvited Review Interactions of nanoparticles with pulmonary structures and cellular responses
Mühlfeld C, Rothen-Rutishauser B, Blank F, Vanhecke D, Ochs M, Gehr P. Interactions of nanoparticles with pulmonary structures and cellular responses. Am J Physiol Lung Cell Mol Physiol 294: L817–L829, 2008. First published February 8, 2008; doi:10.1152/ajplung.00442.2007.—Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers a...
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In order for nanoparticles (NPs) to be applied in the biomedical field, a thorough investigation of their interactions with biological systems is required. Although this is a growing area of research, there is a paucity of comprehensive data in cell-based studies. To address this, we analyzed the physicomechanical responses of human alveolar epithelial cells (A549), mouse fibroblasts (NIH3T3), ...
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The interactions with the pulmonary surfactant, the initial biological barrier of respiratory pathway, determine the potential therapeutic applications and toxicological effects of inhaled nanoparticles (NPs). Although much attention has been paid to optimize the physicochemical properties of NPs for improved delivery and targeting, shape effects of the inhaled NPs on their interactions with th...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2008
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00442.2007