Interferon- impacts at multiple points during the progression of autoimmune diabetes
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Interferon-g impacts at multiple points during the progression of autoimmune diabetes (nonobese diabetic miceyknock-out miceyautoimmune diseaseycytokine)
The role of interferon-g in autoimmune diabetes was assessed by breeding a null mutation of the interferon-g receptor a chain into the nonobese diabetic mouse strain, as well as into a simplified T cell receptor transgenic model of diabetes. In contrast to a previous report on abrogation of the interferon-g gene, mutation of the gene encoding its receptor led to drastic effects on disease in bo...
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Metabolic Regulation in Progression to Autoimmune Diabetes
Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of typ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.25.13844