Interferon Regulatory Factor 4: Combinational Control of Lymphocyte Differentiation
نویسندگان
چکیده
منابع مشابه
IRF4 (interferon regulatory factor 4)
Other names: IRF-4; NF-EM5; LSIRF (lymphocytespecific interferon regulatory factor); MUM1 (multiple myeloma oncogene 1) HGNC (Hugo): IRF4 Location: 6p25.3 Local order: IRF4 is located on chromosome 6 at the telomeric extremity of the short arm, and lies between the DUSP22 (dual specificity phosphatase 22) and EXOC2 (exocyst complex component 2) genes. Note: IRF4 belongs to the IRF (interferon r...
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Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We show that interferon regulatory factor-4 (IRF-4) regulates both processes by controlling the expression of the Aicda and Prdm1 genes, which encode AID and Blimp-1, respectively. Genome-wide analysis demonstrated that Irf4(-/-) B cells failed to induce the entire Blimp...
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ژورنال
عنوان ژورنال: Immunity
سال: 2010
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2010.08.007