Interferon regulatory factor 7- (IRF7-) mediated immune response affects Newcastle disease virus replication in chicken embryo fibroblasts
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چکیده
منابع مشابه
Transcriptional Innate Immune Response of the Developing Chicken Embryo to Newcastle Disease Virus Infection
Traditional approaches to assess the immune response of chickens to infection are through animal trials, which are expensive, require enhanced biosecurity, compromise welfare, and are frequently influenced by confounding variables. Since the chicken embryo becomes immunocompetent prior to hatch, we here characterized the transcriptional response of selected innate immune genes to Newcastle dise...
متن کاملHumoral Immune Response Induced by PLGA Micro Particle Coupled Newcastle Disease Virus Vaccine in Chickens
This experiment was conducted for evaluating the humoral immune responses induced by Poly Lactide-co-Glycolide Acid (PLGA) microspheres coupled inactivated Newcastle Disease Virus (NDV) vaccine in comparison to an ‘in-house’ prepared inactivated and a live commercial vaccine. PLG microparticles containing inactivated NDV were prepared by a double emulsion technique based on solvent evaporation ...
متن کاملThe Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication
Background: Non-ionic surfactant, Tween-80 (TW80) is commonly used for drug delivery due to its effect on the cell membrane permeation. The change in permeability can also increase viral infectivity in cells. This study was undertaken to improve upon Newcastle disease virus (NDV) titer cultivated with embryonic chicken eggs. Methods: The toxicity of TW80 was investigated against chicken embryo...
متن کاملInduction of Intestinal Immune Response to Lentogenic Vaccine Strain of Newcastle Disease Virus in Chicken
Mucosal surface provide portal entry for a majority of infectious agents. Hence, protection at the mucosal surface through immunization plays an important role in containing its systemic spread. Mucosal vaccination of chicken at early stages of life with live attenuated strain of Newcastle disease virus (NDV) induces both cellular and humoral immune responses against the Newcastle disease. In o...
متن کاملReplication of Newcastle Disease Virus
Infection of L cells with Newcastle disease virus (NDV) results in abortive replication, with the production of very few plaque-forming units (PFU) of virus per cell (W. C. Wilcox, Virology 9:30, 1959; K. Paucker et al., Virology 17:301, 1962). It is known that interferon is synthesized by L cells infected with NDV, and the possibility exists that this endogenously produced inhibitor may be res...
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ژورنال
عنوان ژورنال: Acta Veterinaria Hungarica
سال: 2014
ISSN: 0236-6290,1588-2705
DOI: 10.1556/avet.2014.023