Interleukin-11 (IL-11) enhances clonal proliferation of acute myelogenous leukemia cells with strong expression of the IL-11 receptor α chain and signal transducing gp130
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چکیده
منابع مشابه
Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist.
We have expressed a soluble N-glycosylated form of the murine interleukin-11 (IL-11) receptor alpha-chain (sIL-11R) and examined signaling in cells expressing the gp130 molecule. In the presence of gp130 but not the transmembrane IL-11R, the sIL-11R mediated IL-11-dependent differentiation of M1 leukemic cells and proliferation in Ba/F3 cells. Early intracellular events stimulated by the sIL-11...
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Previous investigations have shown that interleukin (IL)-11/IL-11 receptor alpha-chain (IL-11Ralpha), a member of the PI3K, MAPK and JAK-STAT activating family of cytokines/receptors, correlates with the regulation of tumor progression. In this study, we established the IL-11/IL-11Ralpha expression profile in human colorectal adenocarcinoma (CRC) and clarified its signaling pathway and role in ...
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Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain reaction. Significant levels of IL-6 were expressed in 8 (21%) of 39 AML patient...
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[73] Assignee: The United States of America as Vector Processor Architecture for Real-Time Control”, IEEE, Nov. 1989. Ling et al., A VLSI Robotics Vector Processor For Real-Time Control; IEEE, 1988. Amin-Javaheri et al., “Systolic Architecture for the Manipulator Inertia Matrix”, IEEE Dec. 1988. Fijany et al., “A Class of Parallel Algorithms for Computation of the Manipulator Inertia Matrix”, N...
متن کاملTranscytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and gp130. Here, we show that IL-11 signaling via IL-11R1/2:gp130 complexes occurs on both the apical and basolateral sides of polarized cells, whe...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1999
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401433