Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
نویسندگان
چکیده
منابع مشابه
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of...
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ژورنال
عنوان ژورنال: Immunity
سال: 2011
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2011.02.018