Intermittent hyperbaric oxygen exposure mobilizing peroxiredoxin 6 to prevent oxygen toxicity

Central nervous system oxygen toxicity during routine hyperbaric oxygen therapy.

Hyperbaric oxygen therapy is associated with a recognized risk for clinically apparent central nervous system (CNS) toxicity. The risk for oxygen-induced convulsions during routine hyperbaric treatment of most routine conditions is extremely low. However, reports from the 1980's describing the incidence of CNS oxygen toxicity differ significantly from more recent reports since 1996. This retros...

Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures.

INTRODUCTION The use of hyperbaric oxygen (O2) as a therapeutic agent carries with it the risk of central nervous system (CNS) O2 toxicity. METHODS To further the understanding of this risk and the nature of its molecular mechanism, a review was conducted on the literature from various fields. RESULTS Numerous physiological changes are produced by increased partial pressures of oxygen (Po2)...

Oxygen toxicity related to exposure to lead.

We evaluated superoxide dismutase (EC 1.15.1.1) and glutathione peroxidase (EC 1.11.1.9) activities in the erythrocytes of lead-exposed and nonexposed workers from distinct industries localized in the State of São Paulo, Brazil. Concentrations of either lead or protoporphyrin IX, or both, in blood were used to indicate the extent of exposure. In all cases, values for superoxide dismutase were s...

Neurologic Hazards of Hyperbaric Oxygen Exposure.

Exposure to Hyperbaric Oxygen Intensified Vancomycin-Induced Nephrotoxicity in Rats.

It has been suggested that oxidative stress is a potential mechanism for vancomycin-induced nephrotoxicity and hyperbaric oxygen therapy (HBO) has been shown to be effective in treating renal toxicity that has been pharmacologically induced in animal models. The aim of this study was to investigate the effect of HBO therapy on vancomycin-induced nephrotoxicity in rats. The study group comprised...