Internal Experts Collaborate to Reduce Critical Hypoglycemia and Insulin Errors and Improve Insulin Administration Timing

Diabetes and hypoglycemia due to insulin antibodies.

A patient with "autoimmune diabetes" with reactive hypoglycemia due to anti-insulin antibodies is described. The pathophysiology of the impaired carbohydrate tolerance and reactive hypoglycemia is illustrated by measurements of C-peptide, and free and antibody-bound insulin. Detailed analysis of her antibodies did not provide any evidence in favor of exogenous insulin immunization. Nevertheless...

A change to 100-unit insulin dosage will reduce errors.

Patients with diabetes were first treated with insulin in 1922. Insulin was then prepared at a concentration of 20 units/ ml, but later insulin strengths of 40 and 80 units/ml were introduced to reduce the injected volume. For patients needing very large doses, strengths of 320 and 500 units/ml have also been manufactured. The original insulin syringe was designed with 20 divisions (marks) per ...

The Effect of Co-administration of Pioglitazone and Simvastatin on Insulin Resistance Parameters and PPAR.γ Expression in Insulin-resistant Rats

Backgrounds: Insulin resistance is a pathological condition associated with metabolic syndrome. In this condition, insulin action in liver, muscles, and adipocytes decreases which leads to hyperglycemia, hyperinsulinemia, and dyslipidemia. Thiazolidinediones (Pioglitazone) have been used to enhance insulin sensitivity but due to dyslipidemia associated with insulin resistance, ...

Insulin Therapy and Hypoglycemia - Present and Future

Preabsorptive insulin release and hypoglycemia in rats.

Peripheral blood glucose and immunologically reactive insulin levels were determined in freely moving normal rats which were submitted either to a free oral glucose load or to a gastric administration of the glucose load. Identical determinations were performed in ventromedial hypothalamic nucleus-(VMH) lesioned and vagotomized rats after the same oral intake. It was demonstrated that: 1) a fre...