Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator
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چکیده
منابع مشابه
Interstitial cystitis antiproliferative factor (APF) as a cell-cycle modulator
BACKGROUND Interstitial cystitis (IC) is a chronic bladder disorder of unknown etiology. Antiproliferative factor (APF), a peptide found in the urine of IC patients, has previously been shown to decrease incorporation of thymidine by normal bladder epithelial cells. This study was performed to determine the effect of APF on the cell cycle of bladder epithelial cells so as to better understand i...
متن کاملAntiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome
A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause for this disease. Several mechanistic approaches have been employed to address the underlying mechanism whereby APF regulates cellular responses in the bladder epithelium. A s...
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Painful bladder syndrome/interstitial cystitis (PBS/IC) encompasses a major portion of the “painful bladder” disease complex. “Painful bladder disorders” comprise a large group of patients with bladder and/or urethral and/or pelvic pain, irritative voiding symptoms (urgency, frequency, nocturia, and dysuria), and sterile urine cultures. Painful bladder conditions with well-established causes in...
متن کاملChanges in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment.
Explanted bladder epithelial cells from patients with interstitial cystitis (IC) have been shown to differ from explanted control cells in several ways, including production of an antiproliferative factor (APF), altered production of certain epithelial growth factors, and rate of proliferation. To better understand the role of the APF in abnormal bladder epithelial cell proliferation in IC, we ...
متن کاملAn antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide.
Approximately 1 million people in the United States suffer from interstitial cystitis, a chronic painful urinary bladder disorder characterized by thinning or ulceration of the bladder epithelial lining; its etiology is unknown. We have identified a glycosylated frizzled-related peptide inhibitor of cell proliferation that is secreted specifically by bladder epithelial cells from patients with ...
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ژورنال
عنوان ژورنال: BMC Urology
سال: 2004
ISSN: 1471-2490
DOI: 10.1186/1471-2490-4-3