Intimal Hyperplasia in Rats after Subcutaneous Injection of a Somatostatin Analog
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چکیده
منابع مشابه
Intimal hyperplasia in rats after subcutaneous injection of a somatostatin analog.
The somatostatin analog octreotide was administered to male and female Sprague-Dawley rats by subcutaneous injection for thirteen weeks at 0 (saline control), 0 (placebo control [mannitol and lactic acid; pH 4.2]), 1.25 mg/kg/day and 2.5 mg/kg/day to explore its potential effect on cutaneous vascular morphology. The placebo caused an increase in the incidence of intimal hyperplasia compared to ...
متن کاملTacrolimus inhibits intimal hyperplasia in arterialised veins in rats.
OBJECTVES We investigated whether tacrolimus (FK506) can inhibit neointimal formation in arterialised vein grafts in rats. METHODS Lewis iliolumbar veins were implanted into the abdominal aorta of isogeneic rats. Animals in the treatment groups had daily intramuscular injections of tacrolimus at 0.2 mg/kg (group B) and 0.1 mg/kg (Group C), respectively. The control group A had no treatment. L...
متن کاملFlow affects development of intimal hyperplasia after arterial injury in rats.
This study examined the effects of blood flow on intimal hyperplasia after balloon catheter injury of the rat common carotid artery. Flow was altered by ligation of the opposite common carotid artery (increased flow) or of the ipsilateral internal carotid artery (decreased flow). Blood flow decreased by 35% in the low-flow group and increased by 29% in the high-flow group. Similar changes in me...
متن کاملAngiopeptin inhibits intimal hyperplasia after angioplasty in porcine coronary arteries.
BACKGROUND Restenosis is mediated by uncontrolled neointimal growth at the site of coronary angioplasty. Angiopeptin is an octapeptide analogue of somatostatin that has been shown to decrease the experimental intimal hyperplasia associated with vascular injury in rats and rabbits. The study purpose was to determine if angiopeptin inhibits the development of intimal hyperplasia in normolipemic s...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2009
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623308329284