Intracellular delay limits cyclic changes in gene expression

Intracellular delay limits cyclic changes in gene expression.

Based on previously published experimental observations and mathematical models for Hes1, p53 and NF-kappaB gene expression, we improve these models through a distributed delay formulation of the time lag between transcription factor binding and mRNA production. This description of natural variability for delays introduces a transition from a stable steady state to limit cycle oscillations and ...

Stochastic gene expression with delay.

The expression of genes usually follows a two-step procedure. First, a gene (encoded in the genome) is transcribed resulting in a strand of (messenger) RNA. Afterwards, the RNA is translated into protein. We extend the classical stochastic jump model by adding delays (with arbitrary distributions) to transcription and translation. Already in the classical model, production of RNA and protein co...

Role of intracellular Ca2+ overload in inducing changes in cardiac gene expression

Institute of Cardiovascular Sciences, St Boniface Hospital Research; Department of Physiology & Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba Correspondence: Dr Naranjan S Dhalla, Institute of Cardiovascular Sciences, St Boniface Hospital Research, 351 Tache Avenue, Winnipeg, Manitoba R2H 2A6. Telephone 204-235-3417, fax 204-237-034...

Gene Expression Changes under Cyclic Mechanical Stretching in Rat Retinal Glial (Müller) Cells

OBJECTIVE The retina is subjected to tractional forces in various conditions. As the predominant glial element in the retina, Müller cells are active players in all forms of retinal injury and disease. In this study, we aim to identify patterns of gene expression changes induced by cyclic mechanical stretching in Müller cells. METHODS Rat Müller cells were seeded onto flexible bottom culture ...

Gene expression changes in schizophrenia