Intramolecular Regulation of MyoD Activation Domain Conformation and Function
نویسندگان
چکیده
منابع مشابه
Intramolecular regulation of MyoD activation domain conformation and function.
The MyoD family of basic helix-loop-helix (bHLH) proteins is required for myogenic determination and differentiation. The basic region carries the myogenic code and DNA binding specificity, while the N terminus contains a potent transcriptional activation domain. Myogenic activation is abolished when the basic region, bound to a myogenic E box, carries a mutation of Ala-114. It has been propose...
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The ability of transcriptional activation domains (TADs) to signal ubiquitin-mediated proteolysis suggests an involvement of the ubiquitin-proteasome pathway in transcription. To probe this involvement, we asked how ubiquitylation regulates the activity of a transcription factor containing the VP16 TAD. We show that the VP16 TAD signals ubiquitylation through the Met30 ubiquitin-ligase and that...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.9.5478