Intrauterine instillation of granulocyte colony stimulating factor for infertile women with thin endometrium in intrauterine insemination cycle: a non-randomized clinical trial

Background: Endometrial thickness is one of the major factors for a receptive endometrium and successful implantation. Thin endometrium, generally measuring <7 mm are thought to be less able support implantation pregnancy. Several adjuvants have been investigated their efficacy on thin in assisted reproductive technology. Granulocyte colony stimulating factor (G-CSF) glycoprotein that promotes endometrial stromal cell decidualization via cyclic adenosine monophosphate mediator induces proliferation differentiation. This study was done evaluate effect G-CSF improving pregnancy rate infertile patients undergoing stimulated IUI (intrauterine instillation) having endometrium.Methods: non-randomized clinical trial among 40 with (<7 mm) day ovulation trigger patients. Study subjects were non randomly allocated into 2 groups. In group A 20 received intrauterine instillation (300 mcg/0.5 ml) catheter triggering B another 0.5 ml normal saline same procedure. After 48 hours measured both day. Pregnancy detected by serum beta hCG level after 14 days IUI.Results: groups most respondents aged between 30-34 years, (70%) 11 (55%) B. The mean±SD age 32.4±3.1 A, 32.2±3.4 P value 0.9. minimum 4.4 treatment G-CSF, it found 6.3 mm. maximum recorded 6.9 also increased 8.7 followed min 4.8 increase 5.2 max 6.8 ET (mm) ovarian 5.8±0.8 which 7.4±0.8 5.9±0.6 7.1±0.9 mean change (mean±SD) 1.6±0.7 greater than 1.3±0.8. (10%) 1(5%) B.Conclusions: Mean higher group, but difference not statistically significant.