Intrinsic Stability Study and Forced Degradation Profiling of Olopatadine Hydrochloride by RP-HPLC-DAD-HRMS Method
نویسندگان
چکیده
منابع مشابه
A Novel Validated RP-HPLC-DAD Method for the Simultaneous Estimation of Metformin Hydrochloride and Canagliflozin in Bulk and Pharmaceutical Tablet Dosage form with Forced Degradation Studies
A novel approach was used to develop and validate a rapid isocratic Reversed Phase-High Performance Liquid Chromatographic method for the simultaneous estimation of Metformin Hydrochloride and Canagliflozin in bulk and pharmaceutical tablet dosage form with forced degradation studies. The separation was performed by using Kromasil C18 column (250mm×4.6 mm, 5mm particle size), Waters Alliance e2...
متن کاملA Stability-Indicating HPLC-DAD Method for Determination of Ferulic Acid into Microparticles: Development, Validation, Forced Degradation, and Encapsulation Efficiency
A simple stability-indicating HPLC-DAD method was validated for the determination of ferulic acid (FA) in polymeric microparticles. Chromatographic conditions consisted of a RP C18 column (250 mm × 4.60 mm, 5 μm, 110 Å) using a mixture of methanol and water pH 3.0 (48 : 52 v/v) as mobile phase at a flow rate of 1.0 mL/min with UV detection at 320 nm. The developed method was validated as per IC...
متن کاملSimultaneous Estimation of Phenylpropanolamine Hydrochloride and Triprolidine Hydrochloride in Pharmaceutical Preperations by Rp- Hplc Method
A simple and precise reversed phase HPLC method was developed for the stimulation estimation of phenylpropanolamine and triprolidine in tablet formulation. The method was carried out on a shimpack C8 (25 cm x 4.6mm i.d., 5μ) column with a mobile phase consisting of Acetonitrile: phosphate buffer (25mM) of pH 3.0 (35:65v/v) at a flow rate of 1.2ml/min.detection was carried out at 210 nm. The gua...
متن کاملStability-Indicating HPLC-DAD Method for the Determination of Granisetron Hydrochloride in Its Pharmaceutical Preparations
Article history: Received on: 15/03/2013 Revised on: 04/04/2013 Accepted on: 01/05/2013 Available online: A selective and reproducible high performance liquid chromatographic method has been developed for the determination of granisetron hydrochloride in presence of its hydrolytic, oxidation, photodecomposition and thermal degradation products. Successful separation of granisetron from its degr...
متن کاملRP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions.
A simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C(18) column with the mobile phase composed of methanol, acetonitrile and water (60:15:25, V/V/V, pH 3.5 by orthophosphoric acid)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Turkish Journal of Pharmaceutical Sciences
سال: 2019
ISSN: 1304-530X,2148-6247
DOI: 10.4274/tjps.galenos.2018.83007