InVivo Molecular Ultrasound Assessment of Glioblastoma Neovasculature with Endoglin-Targeted Microbubbles
نویسندگان
چکیده
منابع مشابه
Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin.
BACKGROUND Routine methods capable of assessing tissue inflammation noninvasively are currently not available. We hypothesized that tissue retention of microbubbles targeted to the endothelial cell adhesion molecule P-selectin would provide a means to assess inflammation with ultrasound imaging. METHODS AND RESULTS Phospholipid microbubbles targeted to P-selectin (MB(p)) were created by conju...
متن کاملUltrasound with microbubbles
Conventional ultrasound has well known short comings in the detection and characterisation of focal liver lesions. A false negative rate of up to 30% has been quoted in the detection of liver metastases and its accuracy in the characterisation of focal liver lesions is poor compared to computed tomography (CT) and magnetic resonance (MR). Ultrasound microbubble contrast agents have redressed th...
متن کاملNoninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins.
BACKGROUND Noninvasive methods for characterizing neovessel formation during angiogenesis are currently lacking. We hypothesized that angiogenesis could be imaged with the use of contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins. METHODS AND RESULTS Microbubbles targeted to alpha(v)-integrins were prepared by conjugating echistatin (MB(E)) or monoclonal antib...
متن کاملMolecular imaging of endothelial progenitor cell engraftment using contrast-enhanced ultrasound and targeted microbubbles.
AIMS Imaging methods to track the fate of progenitor cells after their delivery would be useful in assessing the efficacy of cell-based therapies. We hypothesized that contrast-enhanced ultrasound (CEU) using microbubbles targeted to a genetically engineered cell-surface marker on endothelial progenitor cells (EPCs) would allow the targeted imaging of vascular engraftment. METHODS AND RESULTS...
متن کاملIn vitro characterization and in vivo ultrasound molecular imaging of nucleolin-targeted microbubbles.
Nucleolin (NCL) plays an important role in tumor vascular development. An increased endothelial expression level of NCL has been related to cancer aggressiveness and prognosis and has been detected clinically in advanced tumors. Here, with a peptide targeted to NCL (F3 peptide), we created an NCL-targeted microbubble (MB) and compared the performance of F3-conjugated MBs with non-targeted (NT) ...
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ژورنال
عنوان ژورنال: Contrast Media & Molecular Imaging
سال: 2018
ISSN: 1555-4309,1555-4317
DOI: 10.1155/2018/8425495