Involvement of Kallikrein-Related Peptidases in Nervous System Disorders
نویسندگان
چکیده
منابع مشابه
Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes
Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of seve...
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INTRODUCTION Novel therapeutic compounds are needed for prostate cancer (CaP), given the limitations of already used drugs and the disease's mortality, often attributed to castrate resistance. Tissue kallikrein and kallikrein-related peptidases (KLKs) form a family of serine proteases aberrantly expressed and broadly implicated in human malignancies. In CaP, KLKs participate in the promotion of...
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..................................................................................................................................... ii Dedication ................................................................................................................................ iii Acknowledgments .......................................................................................................
متن کاملInterdependence of kallikrein-related peptidases in proteolytic networks.
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short pro-peptide. We searched for interconnection of KLKs within extracellular proteolytic networks leading to activation of protease zymogens and found that (i) pro-KLK activ...
متن کاملClinical utility of kallikrein-related peptidases (KLK) in urogenital malignancies.
Kallikrein-related peptidases (KLK), which represent a major tissue-associated proteolytic system, stand for a rich source of biomarkers that may allow molecular classification, early diagnosis and prognosis of human malignancies as well as prediction of response or failure to cancer-directed drugs. International research points to an important role of certain KLKs in female and male urogenital...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2020
ISSN: 1662-5102
DOI: 10.3389/fncel.2020.00166