Involvement of the Amygdala on Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
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چکیده
منابع مشابه
[Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats].
Signs characteristic of opiate withdrawal symptoms can be precipitated by an opiate antagonist after short-term infusion or even a single dose of an opiate both in humans and in animals. This phenomenon has been referred to as acute dependence. In contrast to extensive studies on chronic dependence, less is known about the neural mechanisms mediating acute dependence. It will benefit the develo...
متن کاملReversal Effect of Intra-Central Amygdala Microinjection of L-Arginine on Place Aversion Induced by Naloxone in Morphine Conditioned Rats
Background: Role of nitric oxide (NO) on expression of morphine conditioning using a solely classic task has been proposed previously. In this work, the involvement of NO on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. Methods: Conditioning was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedu...
متن کاملBlockade of the Naloxone-induced Aversion in Morphine-conditioned Wistar Rats by L-Arginine Intra-central Amygdala
Objective(s) Single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. Materials and Methods Conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedure. Nitric oxide agents were microinjected into the central amygdala pri...
متن کاملreversal effect of intra-central amygdala microinjection of l-arginine on place aversion induced by naloxone in morphine conditioned rats
background: role of nitric oxide (no) on expression of morphine conditioning using a solely classic task has been proposed previously. in this work, the involvement of no on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. methods: conditioning was established in adult male wistar rats (weighing 200-250 g) using an unbiased procedu...
متن کاملReversal effect of intra-central amygdala microinjection of L-arginine on place aversion induced by naloxone in morphine conditioned rats.
BACKGROUND Role of nitric oxide (NO) on expression of morphine conditioning using a solely classic task has been proposed previously. In this work, the involvement of NO on the expression of opioid-induced conditioning in the task paired with an injection of naloxone was investigated. METHODS Conditioning was established in adult male Wistar rats (weighing 200-250 g) using an unbiased procedu...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2008
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.128.395