Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation
نویسندگان
چکیده
منابع مشابه
: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes
هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...
Ubiquilin-1 and protein quality control in Alzheimer disease
Single nucleotide polymorphisms in the ubiquilin-1 gene may confer risk for late-onset Alzheimer disease (AD). We have shown previously that ubiquilin-1 functions as a molecular chaperone for the amyloid precursor protein (APP) and that protein levels of ubiquilin-1 are decreased in the brains of AD patients. We have recently found that ubiquilin-1 regulates APP trafficking and subsequent secre...
متن کاملUbiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
The pathogenesis of Alzheimer's disease (AD) is associated with proteolytic processing of the amyloid precursor protein (APP) to an amyloidogenic peptide termed Aβ. Although mutations in APP and the secretase enzymes that mediate its processing are known to result in familial forms of AD, the mechanisms underlying the more common sporadic forms of the disease are still unclear. Evidence suggest...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
متن کاملRuminal Protein Degradation and Estimation of Rumen Microbial Protein Production
Animal agricultural production systems are major sources of nonpoint pollution affecting quality of water sources. Nitrogen has been identified as the foremost source of nonpoint water pollution and the potential negative impacts of N have become an area of public concern. protein degradation from feed ingredients is an important factorinfluencing AA supply to the duodenum. Ruminal proteolysis...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2011
ISSN: 1942-0889
DOI: 10.4161/cib.15283