Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK
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منابع مشابه
Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK
XRCC4 (X-ray cross-complementation group 4) is a protein associated with DNA ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end-joining. It has been shown that, in response to irradiation or treatment with DNA damaging agents, XRCC4 undergoes phosphorylation, requiring DNA-PK. Here we explored possible role of ATM, whi...
متن کاملATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2AX phosphorylation after exposure to ionizing radiation (IR) occurs to similar...
متن کاملH2AX after Exposure to Ionizing Radiation ATM and DNA-PK Function Redundantly to Phosphorylate
H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2AX phosphorylation after exposure to ionizing radiation (IR) occurs to similar...
متن کاملIn cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage
XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 and Ser320 (or Ser318 in alternatively spliced form) of XRCC4 were identified ...
متن کاملActivation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6
DNA-dependent protein kinase (DNA-PK) plays a critical role in DNA damage repair, especially in non-homologous end-joining repair of double-strand breaks such as those formed by ionizing radiation (IR) in the course of radiation therapy. Regulation of DNA-PK involves multisite phosphorylation but this is incompletely understood and little is known about protein phosphatases relative to DNA-PK. ...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2014
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.90.365