Irisin: A myokine with locomotor activity
نویسندگان
چکیده
منابع مشابه
Irisin – a myth rather than an exercise-inducible myokine
The myokine irisin is supposed to be cleaved from a transmembrane precursor, FNDC5 (fibronectin type III domain containing 5), and to mediate beneficial effects of exercise on human metabolism. However, evidence for irisin circulating in blood is largely based on commercial ELISA kits which are based on polyclonal antibodies (pAbs) not previously tested for cross-reacting serum proteins. We hav...
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Obesity is a worldwide health problem that results in a signifi cant increased risk of morbidity and mortality. While we know that obesity is the consequence of a chronic imbalance between energy intake and energy expenditure, how energy expenditure is regulated in humans is not clearly understood. Recent publications suggest that specifi c depots of white adipose tissue can be converted to the...
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Osteoporosis, the skeletal disease characterized by decrease of bone mass and deterioration of its microarchitecture, and Sarcopenia, the muscle disease characterized by progressive loss of muscle mass and strength, are often concurrent diseases affecting the elderly population. These associated pathologies represent one of the major threats that increase the risk of fall-related fracture durin...
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1. Matsuo Y, Gleitsmann K, Mangner N, Werner S, Fischer T, Bowen TS, et al. Fibronectin type III domain containing 5 expression in skeletal muscle in chronic heart failure-relevance of inflammatory cytokines. J Cachexia Sarcopenia Muscle 2015;6:62–72. 2. Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, et al. Cachexia: a new definition. Clin Nutr 2008;27:793–799. 3. von Haehling...
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Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many of the molecular events responsible for the curative and protective role of exercise remain elusive. The recent discovery of FNDC5/irisin protein that is liberated by muscle tissue in response to exercise might be an important finding with regard to this unsolved mechanism. The most striking aspect...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2015
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2015.03.069