Irreversible Inactivation of Glutathione Peroxidase 1 and Reversible Inactivation of Peroxiredoxin II by H2O2in Red Blood Cells
نویسندگان
چکیده
منابع مشابه
Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells
Peroxiredoxin 2 (Prx2) is the third most abundant protein in red blood cells (RBCs). In this study, we have succeeded in implementing the rapid and simultaneous detection of the hyperoxidized (Prx2-SO2/3) and reduced (Prx2-SH) forms of Prx2 in human RBCs using reverse phase high-performance liquid chromatography. The detection of a peak corresponding to Prx2-SO2/3 was clearly observed following...
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Introduction: Several supra spinal areas such as rostral ventrolateral medulla (RVLM) area are involved in basic cardiovascular regulation. The Kolliker— Fuse nucleus (KF) is located in pons and is heavily connected with RVLM. The cardiovascular effect of KF nucleus has been shown and it is suggested that KF is involved in sympathetic vasomotor tone and basic cardiovascular regulation. Therefor...
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The role of raphe nucleus (R.N) and serotonin in some behaviors such as sleep, cognition, mood, and memory has previously been reported. The median raphe (MR) nucleus is a major serotonin-containing cell group within the brainstem and is one of the main sources of projections to the septum and hippocampus. The hippocampus is widely believed to be essential for context-conditioning learning. Mor...
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The anticancer anthracyclines, doxorubicin and daunorubicin, are highly cytotoxic to both cancer and normal cells. In this work, we have investigated the capacity of cellular myeloperoxidase to inactivate these agents. We show that incubation of human leukemia HL-60 cells with the anthracyclines in the presence of hydrogen peroxide and nitrite causes irreversible oxidation of the drugs, suggest...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2010
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2009.2701